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Cyanide toxicity USDA ARS

Cyanide is more strongly drawn to methemoglobin than to the cytochrome oxidase of the cells, effectively pulling the cyanide off the cells and onto the methemoglobin. Once bound with the cyanide, the Methemoglobin becomes cyanmethemoglobin. The next part of the cyanide antidote kit is sodium thiosulfate, which is administered IV. The sodium

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Hazardous-Materials Antidotes EMS World

Victims of hydrogen cyanide poisoning are treated with the contents of a cyanide antidote kit, which includes amyl nitrite, sodium nitrite and sodium thiosulfate. Formerly known as the Lilly Kit

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Cyanide Poisoning and Its Treatment

treatment for cyanide toxicity approved for use in the United States is a kit consisting of amyl nitrite, sodium nitrite, and sodium thiosulfate (Cyanide Antidote Kit; Acorn Inc., Buffalo Grove, IL). It was formerly known as the Pasadena or Lilly Kit. It is important for health professionals to be aware of potential sources of cyanide, its

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DGR Industrial Products, Inc. Sodium Cyanide MSDS

IN CASE OF CYANIDE POISONING, start first aid treatment immediately, then get medical attention. A cyanide antidote kit (amyl nitrite, sodium nitrite and sodium thiosulfate) should be available in any cyanide work area. Actions to be taken in case of cyanide poisoning should be planned and practiced before beginning work with cyanides.

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SODIUM CYANIDE hazard

A cyanide antidote kit (amyl nitrite, sodium nitrite and sodium thiosulfate) should be available in any cyanide work area. Actions to be taken in case of cyanide poisoning should be planned and practiced before beginning work with cyanides. Oxygen and amyl nitrite can be given by a first responder before medical help arrives.

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Traditional Cyanide antidote kit now off the market in

Cyanide is highly toxic by all routes of exposure and may rapidly impair the nervous, cardiovascular and respiratory systems leading to death within minutes to hours. Gold mines and mills have historically used a Cyanide Antidote Kit (CAK) that contains three components amyl nitrite, sodium nitrite, and sodium thiosulfate.

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Cyanide toxicity WikEM

Cyanide Antidote Package (Lilly kit) Composed of two drugs(2 nitrites and a thiosulfate). Dixon PS, Valtier S, Bush A. Hydroxocobalamin and sodium thiosulfate versus sodium nitrite and sodium thiosulfate in the treatment of acute cyanide toxicity in a swine (Sus scrofa) model. Ann Emerg Med. 2010;55(4)345-51.

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Cyanide Poisoning California Poison Control System UCSF

Mar 19, 2008The most well known cyanide antidote kit (manufactured by Lily, Taylor, and others), consists of amyl nitrite, sodium nitrite and sodium thiosulfate. Amyl nitrite (which is given by inhalation) and sodium nitrite (300 mg or 10 mg/kg given intravenously) are administered to induce modest methemoglobinemia.

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Hydroxocobalamin Turning Cyanide into Vitamin B12

The older cyanide antidote kits consisted of nitrites and sodium thiosulfate. The true mechanism of action is complicated . In short, the nitrites used in antidote kits are either inhaled amyl nitrite, used typically in the pre-hospital setting or when IV access is not available, or IV sodium nitrite .

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Cyanide Antidote Kits Boston EMS

Part II of Cyanide Antidote Kit Sodium nitrite- DOC if IV access is available. Creates methemoglobinemia more effectively than amyl nitrite. This dose assumes hemoglobin level of 12 mg/dL; dosage adjustment necessary in patients with anemia. Half original dose may be repeated in 1 h if patient continues to exhibit signs of cyanide toxicity.

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Hydrogen Sulfide Toxicity Medication Cyanide Antidotes

Dec 29, 2016Sodium thiosulfate should not be used in the treatment of hydrogen sulfide poisoning. In the classic cyanide antidote kit, sodium nitrite and sodium thiosulfate are provided. The nitrites cause the formation of methemoglobinemia, scavenging both cyanide and hydrogen sulfide.

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CENTER FOR DRUG EVALUATION AND RESEARCH

Product History and Background A three component cyanide antidote kit (amyl nitrite, sodium nitrite, and sodium thiosulfate) was marketed by Eli Lilly as early as 1944. Eli Lilly no longer markets this product; and Akorn is the current supplier of this kit. A search of the web notes that one can obtain a similar kit from ABO Pharmaceuticals

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The Facts About Cyanides

Sodium thiosulfate 50 ml of 25% solution IV over 10 20 minutes If sodium nitrite is unavailable, administer amyl nitrite by inhalation from crushable ampules. If neither is available, use sodium thiosulfate alone. Available from Taylor Pharmaceuticals in cyanide antidote kit, formerly known as the Pasadena or Lilly Kit.

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Akorn Pharmaceuticals Cyanide Antidote Kit

Akorn Pharmaceuticals Cyanide Antidote Kit The combination of Sodium Nitrate and Sodium Thiosulfate is the best therapy against cyanide and hydrocyanic acid poisoning. The 2 substances intravenously injected, one after the other (nitrite followed by the thiosulfate) are capable of detoxifying approximately 1 lethal dose of sodium cyanide and

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A Review of Acute Cyanide Poisoning With a Treatment Update

When the cyanide antidote kit is used, critical care nurses must watch for vasodilatation and hypotension, important adverse effects of nitrites 9 . Sodium nitrite must be administered slowly, over at least 3 to 5 minutes, with frequent blood pressure monitoring.

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Cyanide Fact JHSPH Center for Health Security

Cyanide Antidote Kit This 3-component process comprising amyl nitrite, sodium nitrate, and sodium thiosulfate releases cyanide from cytochrome a3 by providing a target for which cyanide has a higher attraction. Amyl nitrite, contained in pearls that must be broken and inhaled, and IV sodium nitrate cause the formation of methemoglobin, for

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AKORN CYANIDE ANTIDOTE KIT $591.10

Medical Office Supplies Medical Equipment Sales FDI Medical AKORN CYANIDE ANTIDOTE KIT Includes Sodium Nitrite Injection USP (300mg in 10mL), Sodium Thiosulfate Injection USP (12.5g in 50mL), Amyl Nitrite Inhalant (5 min 0.3mL)

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Antidotes (Printable Chart) California Poison Control

(Less expensivethan the Cyanokit™ antidote kit) Immediate emergency department. Sodium Thiosulfate. Cyanide; sodium nitroprusside toxicity. If used alone for cyanide toxicity, may have a slow onset of action. Thiosulfate is synergistic with sodium nitrite, and the two drugs should be used together to treat cyanide poisoning whenever possible.

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ATSDR Medical Management Guidelines (MMGs) Cyanide

There are currently two cyanide antidotal kits approved by the U.S. FDA. Use either the cyanide antidotal kit that includes amyl nitrite perles and intravenous infusions of sodium nitrite and sodium thiosulfate or the recently approved cyanokit that employs intravenous infusion of hydroxocobalamin (FDA 2006; HSDB 2007).

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SAFETY DATA SHEET Sodium Cyanide Solid CSBP

Cyanide Emergency Kit containing Amyl Nitrite Pearls; Hydroxycobalamine and Sodium Thiosulfate; Also administer sodium thiosulfate 125 grams over 10 to 20 minutes with the hydroxycobalamine; SAFETY DATA SHEET Sodium Cyanide Solid ABN 81 008 668 371 CSBP-IF1805

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Cyanide Antidote Suppliers, all Quality Cyanide Antidote

Cyanide Antidote, Cyanide Antidote Suppliers Directory Find variety Cyanide Antidote Suppliers, Manufacturers, Companies from around the World at, Herbicide 99%Min Purity Sodium Nitrite The Antidote To Cyanide Poisoning. Sodium Thiosulfate Supplier Sodium Hyposulfite Supplier

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Sodium Cyanide Chemwatch

Sodium cyanide is an inorganic compound with the formula NaCN. It is a white, water-soluble solid. Sodium cyanide is a deliquescent crystalline powder, which means that it has a strong affinity for moisture and will absorb relatively large amounts of water

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Cyanide Wikipedia

An older cyanide antidote kit included administration of three substances amyl nitrite pearls (administered by inhalation), sodium nitrite, and sodium thiosulfate. The goal of the antidote was to generate a large pool of ferric iron (Fe 3 ) to compete for cyanide with cytochrome a 3 (so

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